Myosin-binding protein H-like (MYBPHL)
Homo sapiens — UniProt A2RUH7
Data last refreshed: (UniProt release unknown)
Key facts
Myosin-binding protein H-like (MYBPHL) is a protein from Homo sapiens identified by UniProt accession A2RUH7, 354 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: A2RUH7; gene symbol MYBPHL.
- Organism: Homo sapiens.
- Length: 354 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, PR interval and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Myosin-binding protein H-like |
|---|---|
| UniProt accession | A2RUH7 |
| Gene | MYBPHL |
| Organism | Homo sapiens |
| Length | 354 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- PR interval · score 0.17
- glomerular filtration rate · score 0.16
- creatinine measurement · score 0.14
- total cholesterol measurement · score 0.13
- hypertrophic cardiomyopathy · score 0.12
- Brugada syndrome · score 0.12
- Non-immune hydrops fetalis · score 0.11
- mathematical ability · score 0.10
- blood protein measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A2RUH7-F1 | alphafold | PREDICTED | 85.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A2RUH7.
Amino-acid sequence (354 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MYBPHL?
The strongest Open Targets associations for MYBPHL are neurodegenerative disease, PR interval, glomerular filtration rate, creatinine measurement and total cholesterol measurement.
How long is the MYBPHL protein?
The Homo sapiens MYBPHL protein (UniProt A2RUH7) is 354 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A2RUH7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A2RUH7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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