Transmembrane protein 131-like (TMEM131L)
Homo sapiens — UniProt A2VDJ0
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 131-like (TMEM131L) is a protein from Homo sapiens identified by UniProt accession A2VDJ0, 1609 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: A2VDJ0; gene symbol TMEM131L.
- Organism: Homo sapiens.
- Length: 1609 amino acids.
- Top disease associations (Open Targets): mean platelet volume, mean corpuscular volume and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 131-like |
|---|---|
| UniProt accession | A2VDJ0 |
| Gene | TMEM131L |
| Organism | Homo sapiens |
| Length | 1609 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.52
- mean corpuscular volume · score 0.50
- platelet count · score 0.47
- reticulocyte count · score 0.47
- platelet component distribution width · score 0.46
- monocyte count · score 0.44
- reticulocyte measurement · score 0.41
- balding measurement · score 0.39
- mean reticulocyte volume · score 0.38
- total blood protein measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A2VDJ0-F1 | alphafold | PREDICTED | 52.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A2VDJ0.
Amino-acid sequence (1609 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM131L?
The strongest Open Targets associations for TMEM131L are mean platelet volume, mean corpuscular volume, platelet count, reticulocyte count and platelet component distribution width.
How long is the TMEM131L protein?
The Homo sapiens TMEM131L protein (UniProt A2VDJ0) is 1609 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A2VDJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A2VDJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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