GTP-binding protein 10 (GTPBP10)
Homo sapiens — UniProt A4D1E9
Data last refreshed: (UniProt release unknown)
Key facts
GTP-binding protein 10 (GTPBP10) is a protein from Homo sapiens identified by UniProt accession A4D1E9, 387 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: A4D1E9; gene symbol GTPBP10.
- Organism: Homo sapiens.
- Length: 387 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, FEV/FVC ratio and homocysteine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GTP-binding protein 10 |
|---|---|
| UniProt accession | A4D1E9 |
| Gene | GTPBP10 |
| Organism | Homo sapiens |
| Length | 387 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- FEV/FVC ratio · score 0.23
- homocysteine measurement · score 0.18
- Blackfan-Diamond anemia · score 0.07
- MODY · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- alpha-thalassemia-myelodysplastic syndrome · score 0.06
- hemoglobin D disease · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A4D1E9-F1 | alphafold | PREDICTED | 80.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A4D1E9.
Amino-acid sequence (387 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTPBP10?
The strongest Open Targets associations for GTPBP10 are neurodegenerative disease, FEV/FVC ratio, homocysteine measurement, Blackfan-Diamond anemia and MODY.
How long is the GTPBP10 protein?
The Homo sapiens GTPBP10 protein (UniProt A4D1E9) is 387 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A4D1E9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A4D1E9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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