Leucine-rich repeat and death domain-containing protein 1 (LRRD1)
Homo sapiens — UniProt A4D1F6
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and death domain-containing protein 1 (LRRD1) is a protein from Homo sapiens identified by UniProt accession A4D1F6, 860 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: A4D1F6; gene symbol LRRD1.
- Organism: Homo sapiens.
- Length: 860 amino acids.
- Top disease associations (Open Targets): hemoglobin measurement, hematocrit and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and death domain-containing protein 1 |
|---|---|
| UniProt accession | A4D1F6 |
| Gene | LRRD1 |
| Organism | Homo sapiens |
| Length | 860 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.30
- hematocrit · score 0.26
- erythrocyte count · score 0.19
- mean corpuscular hemoglobin concentration · score 0.11
- eosinophil count · score 0.11
- eosinophil percentage of leukocytes · score 0.09
- breast carcinoma · score 0.08
- red blood cell density measurement · score 0.08
- self reported educational attainment · score 0.06
- mean platelet volume · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A4D1F6-F1 | alphafold | PREDICTED | 81.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A4D1F6.
Amino-acid sequence (860 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRD1?
The strongest Open Targets associations for LRRD1 are hemoglobin measurement, hematocrit, erythrocyte count, mean corpuscular hemoglobin concentration and eosinophil count.
How long is the LRRD1 protein?
The Homo sapiens LRRD1 protein (UniProt A4D1F6) is 860 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A4D1F6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A4D1F6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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