DENN domain-containing protein 11 (DENND11)
Homo sapiens — UniProt A4D1U4
Data last refreshed: (UniProt release unknown)
Key facts
DENN domain-containing protein 11 (DENND11) is a protein from Homo sapiens identified by UniProt accession A4D1U4, 455 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.
- UniProt accession: A4D1U4; gene symbol DENND11.
- Organism: Homo sapiens.
- Length: 455 amino acids.
- Top disease associations (Open Targets): sensory perception of bitter taste, osteosarcoma and Sepsis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DENN domain-containing protein 11 |
|---|---|
| UniProt accession | A4D1U4 |
| Gene | DENND11 |
| Organism | Homo sapiens |
| Length | 455 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (9)
Diseases linked to this target (Open Targets).
- sensory perception of bitter taste · score 0.20
- osteosarcoma · score 0.01
- Sepsis · score 0.01
- Pick disease · score 0.00
- cancer · score 0.00
- transient ischemic attack · score 0.00
- meningococcal infection · score 0.00
- axial length measurement · score 0.00
- Cerebral ischemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A4D1U4-F1 | alphafold | PREDICTED | 77.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A4D1U4.
Amino-acid sequence (455 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DENND11?
The strongest Open Targets associations for DENND11 are sensory perception of bitter taste, osteosarcoma, Sepsis, Pick disease and cancer.
How long is the DENND11 protein?
The Homo sapiens DENND11 protein (UniProt A4D1U4) is 455 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A4D1U4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A4D1U4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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