Structure-specific endonuclease subunit EME2 (EME2)

About Structure-specific endonuclease subunit EME2

Structure-specific endonuclease subunit EME2 (EME2) is a protein from Homo sapiens identified by UniProt accession A4GXA9, 379 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Structure-specific endonuclease subunit EME2
UniProt accession	A4GXA9
Gene	EME2
Organism	Homo sapiens
Length	379 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

Mitochondrial disorder due to a defect in mitochondrial protein synthesis · score 0.42
neurodegenerative disease · score 0.36
ataxia telangiectasia · score 0.34
Ataxia-telangiectasia · score 0.34
Leigh syndrome · score 0.26
genetic disorder · score 0.18
mitochondrial disease · score 0.12
cortical thickness · score 0.08
sitting height measurement · score 0.07
lean body mass · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A4GXA9-F1	alphafold	PREDICTED	79.94	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for A4GXA9.

Amino-acid sequence (379 residues)

MARVGPGRAG VSCQGRGRGR GGSGQRRPPT WEISDSDAED SAGSEAAARA RDPAGERRAA AEALRLLRPE QVLKRLAVCV DTAILEDAGA DVLMEALEAL GCECRIEPQR PARSLRWTRA SPDPCPRSLP PEVWAAGEQE LLLLLEPEEF LQGVATLTQI SGPTHWVPWI SPETTARPHL AVIGLDAYLW SRQHVSRGTQ QPESPKVAGA EVAVSWPEVE EALVLLQLWA NLDVLLVASW QELSRHVCAV TKALAQYPLK QYRESQAFSF CTAGRWAAGE PVARDGAGLQ AAWRRQIRQF SRVSPAVADA VVTAFPSPRL LQQALEACST ERERMGLLAD LPVPPSEGGR PRRVGPDLSR RICLFLTTAN PDLLLDLGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards