Cilia- and flagella-associated protein 69 (CFAP69)
Homo sapiens — UniProt A5D8W1
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 69 (CFAP69) is a protein from Homo sapiens identified by UniProt accession A5D8W1, 941 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.
- UniProt accession: A5D8W1; gene symbol CFAP69.
- Organism: Homo sapiens.
- Length: 941 amino acids.
- Top disease associations (Open Targets): spermatogenic failure 24, non-syndromic male infertility due to sperm motility disorder and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 69 |
|---|---|
| UniProt accession | A5D8W1 |
| Gene | CFAP69 |
| Organism | Homo sapiens |
| Length | 941 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (118)
Diseases linked to this target (Open Targets).
- spermatogenic failure 24 · score 0.58
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- type 2 diabetes mellitus · score 0.23
- glucose measurement · score 0.22
- FEV/FVC ratio · score 0.19
- pulse pressure measurement · score 0.14
- diastolic blood pressure · score 0.11
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- type 1 diabetes mellitus · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A5D8W1-F1 | alphafold | PREDICTED | 85.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A5D8W1.
Amino-acid sequence (941 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP69?
The strongest Open Targets associations for CFAP69 are spermatogenic failure 24, non-syndromic male infertility due to sperm motility disorder, type 2 diabetes mellitus, glucose measurement and FEV/FVC ratio.
How long is the CFAP69 protein?
The Homo sapiens CFAP69 protein (UniProt A5D8W1) is 941 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A5D8W1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A5D8W1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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