Modulator of macroautophagy TMEM150B (TMEM150B)
Homo sapiens — UniProt A6NC51
Data last refreshed: (UniProt release unknown)
Key facts
Modulator of macroautophagy TMEM150B (TMEM150B) is a protein from Homo sapiens identified by UniProt accession A6NC51, 233 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: A6NC51; gene symbol TMEM150B.
- Organism: Homo sapiens.
- Length: 233 amino acids.
- Top disease associations (Open Targets): age at menopause, aspartate aminotransferase measurement and menopause.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Modulator of macroautophagy TMEM150B |
|---|---|
| UniProt accession | A6NC51 |
| Gene | TMEM150B |
| Organism | Homo sapiens |
| Length | 233 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- age at menopause · score 0.37
- aspartate aminotransferase measurement · score 0.32
- menopause · score 0.24
- body height · score 0.17
- cystatin C measurement · score 0.13
- sitting height measurement · score 0.12
- Barrett's esophagus · score 0.07
- esophageal adenocarcinoma · score 0.04
- nephronophthisis 11 · score 0.03
- hepatorenocardiac degenerative fibrosis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NC51-F1 | alphafold | PREDICTED | 93.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NC51.
Amino-acid sequence (233 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM150B?
The strongest Open Targets associations for TMEM150B are age at menopause, aspartate aminotransferase measurement, menopause, body height and cystatin C measurement.
How long is the TMEM150B protein?
The Homo sapiens TMEM150B protein (UniProt A6NC51) is 233 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NC51 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NC51 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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