RING finger protein 222 (RNF222)

About RING finger protein 222

RING finger protein 222 (RNF222) is a protein from Homo sapiens identified by UniProt accession A6NCQ9, 220 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	RING finger protein 222
UniProt accession	A6NCQ9
Gene	RNF222
Organism	Homo sapiens
Length	220 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

esophageal squamous cell carcinoma · score 0.04
esophageal adenocarcinoma · score 0.04
red blood cell density measurement · score 0.03
Barrett's esophagus · score 0.03
psoriasis · score 0.02
Sepsis · score 0.01
hepatocellular carcinoma · score 0.00
cervical adenocarcinoma · score 0.00
cervical squamous cell carcinoma · score 0.00
Obesity · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NCQ9-F1	alphafold	PREDICTED	62.69	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NCQ9.

Amino-acid sequence (220 residues)

MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTLV CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL DSLGHTNPLA ASSPAWRPPP GQARPPGSPG QSAQLPLDLL PSLPRESQIF VISRHGMPLG EQDSVLPRRS LAELSEASLA PRSARAFCCR SRALLLITLI AVVAVVAAIL PWVLLVRKQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards