Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 (USP17L3)
Homo sapiens — UniProt A6NCW0
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 (USP17L3) is a protein from Homo sapiens identified by UniProt accession A6NCW0, 530 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: A6NCW0; gene symbol USP17L3.
- Organism: Homo sapiens.
- Length: 530 amino acids.
- Top disease associations (Open Targets): hypertension, immunodeficiency 19 and combined immunodeficiency with skin granulomas.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 |
|---|---|
| UniProt accession | A6NCW0 |
| Gene | USP17L3 |
| Organism | Homo sapiens |
| Length | 530 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- hypertension · score 0.08
- immunodeficiency 19 · score 0.04
- combined immunodeficiency with skin granulomas · score 0.03
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia · score 0.03
- severe combined immunodeficiency due to IKK2 deficiency · score 0.03
- ring chromosome Y · score 0.03
- X-Linked Combined Immunodeficiency Diseases · score 0.03
- severe combined immunodeficiency due to LAT deficiency · score 0.03
- obesity due to congenital leptin deficiency · score 0.03
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NCW0-F1 | alphafold | PREDICTED | 67.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NCW0.
Amino-acid sequence (530 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP17L3?
The strongest Open Targets associations for USP17L3 are hypertension, immunodeficiency 19, combined immunodeficiency with skin granulomas, immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia and severe combined immunodeficiency due to IKK2 deficiency.
How long is the USP17L3 protein?
The Homo sapiens USP17L3 protein (UniProt A6NCW0) is 530 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NCW0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NCW0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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