About Paralemmin-3
Paralemmin-3 (PALM3) is a protein
from Homo sapiens identified by UniProt accession
A6NDB9, 673 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Paralemmin-3 |
|---|
| UniProt accession | A6NDB9 |
|---|
| Gene | PALM3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 673 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (37)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.31
- sex hormone-binding globulin measurement · score 0.30
- serum gamma-glutamyl transferase measurement · score 0.30
- testosterone measurement · score 0.21
- low density lipoprotein cholesterol measurement · score 0.19
- blood phosphate measurement · score 0.18
- mean corpuscular volume · score 0.12
- sensorineural hearing loss · score 0.12
- creatinine measurement · score 0.11
- cystatin C measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NDB9-F1 | alphafold | PREDICTED | 50.61 | — |
Amino-acid sequence (673 residues)
MAESSLYRQR LEVIAEKRRL QEEIRAARRE VEEEKLRVER LKRKSLRERW LMDGAAAVPE PSEDPTSKDP QSPEGQAQAR IRNLEDSLFT LQSQLQLLQS ASTGAQHKPS GRPSWRRQGH RPLSQSIVEA GSVGQTDLNK RASLPAGLVG TPPESPSEPR EDVLGFLPGP RQVPGAAGDS SEANGPCPSP IPTPEQGLSQ RAVPSEGRVG EAKGGGVVSV VWEGLRATED CATGATGPEL EAKVEEVVLE AIGDRKGAGS LELPAWVKED RGIVEVVWEG VGGSDAEAMG EIGRVPEVVQ TSSPRLQERL EAAASIEGED VPQGSPEGDG QGGSGGEEGS FIWVERVTLS EEWEELLVEG LEGPEVAGRE RGDESPLGAE GAKTGGGEET WEAEKRKAEE SMGIGSEEKP GTGRDEAEMS PVVERKGGEK KLELESRGSA EKLGTEREGG EEPLGIERKV EGHLRAEKEG DEEKRGAEEE EVEEPLGVEK KGGEEEPEAT KEPLEAERKG GEETLEAEKR GGEESLETEK TQGTEGDLNL EQGSREGSES QAEEMNEAGP PLEANTETRP EKEGPQPQEK PVGALEEEGV KPQTAAEGQG PLGDATPLLA ETPAPEQPAE CQPLLQGEGP SANPSAHPVP TYAPARQPEP SAPTEGEEAS GPKQKTCQCC AVM
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