Putative tripartite motif-containing protein 49B (TRIM49B)
Homo sapiens — UniProt A6NDI0
Data last refreshed: (UniProt release unknown)
Key facts
Putative tripartite motif-containing protein 49B (TRIM49B) is a protein from Homo sapiens identified by UniProt accession A6NDI0, 452 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: A6NDI0; gene symbol TRIM49B.
- Organism: Homo sapiens.
- Length: 452 amino acids.
- Top disease associations (Open Targets): glomerular filtration rate, mean reticulocyte volume and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Putative tripartite motif-containing protein 49B |
|---|---|
| UniProt accession | A6NDI0 |
| Gene | TRIM49B |
| Organism | Homo sapiens |
| Length | 452 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.14
- mean reticulocyte volume · score 0.10
- lymphocyte count · score 0.09
- high density lipoprotein cholesterol measurement · score 0.09
- serum metabolite measurement · score 0.09
- systolic blood pressure · score 0.09
- alcohol drinking · score 0.08
- bone quantitative ultrasound measurement · score 0.07
- IGF-1 measurement · score 0.07
- hypertension · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NDI0-F1 | alphafold | PREDICTED | 85.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NDI0.
Amino-acid sequence (452 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM49B?
The strongest Open Targets associations for TRIM49B are glomerular filtration rate, mean reticulocyte volume, lymphocyte count, high density lipoprotein cholesterol measurement and serum metabolite measurement.
How long is the TRIM49B protein?
The Homo sapiens TRIM49B protein (UniProt A6NDI0) is 452 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NDI0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NDI0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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