Transmembrane protein 8B (TMEM8B)
Homo sapiens — UniProt A6NDV4
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 8B (TMEM8B) is a protein from Homo sapiens identified by UniProt accession A6NDV4, 472 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: A6NDV4; gene symbol TMEM8B.
- Organism: Homo sapiens.
- Length: 472 amino acids.
- Top disease associations (Open Targets): blood protein measurement, cortical surface area measurement and hemojuvelin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 8B |
|---|---|
| UniProt accession | A6NDV4 |
| Gene | TMEM8B |
| Organism | Homo sapiens |
| Length | 472 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.22
- cortical surface area measurement · score 0.17
- hemojuvelin measurement · score 0.17
- serum gamma-glutamyl transferase measurement · score 0.06
- body height · score 0.05
- Red cell distribution width · score 0.04
- hepatocellular carcinoma · score 0.03
- hip circumference · score 0.02
- brain measurement · score 0.02
- protein measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NDV4-F1 | alphafold | PREDICTED | 80.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NDV4.
Amino-acid sequence (472 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM8B?
The strongest Open Targets associations for TMEM8B are blood protein measurement, cortical surface area measurement, hemojuvelin measurement, serum gamma-glutamyl transferase measurement and body height.
How long is the TMEM8B protein?
The Homo sapiens TMEM8B protein (UniProt A6NDV4) is 472 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NDV4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NDV4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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