Embryonic polyadenylate-binding protein 2 (PABPN1L)
Homo sapiens — UniProt A6NDY0
Data last refreshed: (UniProt release unknown)
Key facts
Embryonic polyadenylate-binding protein 2 (PABPN1L) is a protein from Homo sapiens identified by UniProt accession A6NDY0, 278 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: A6NDY0; gene symbol PABPN1L.
- Organism: Homo sapiens.
- Length: 278 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean platelet volume and Female infertility due to fertilization defect.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Embryonic polyadenylate-binding protein 2 |
|---|---|
| UniProt accession | A6NDY0 |
| Gene | PABPN1L |
| Organism | Homo sapiens |
| Length | 278 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- mean platelet volume · score 0.14
- Female infertility due to fertilization defect · score 0.10
- Rare genetic female infertility · score 0.09
- female infertility due to oocyte meiotic arrest · score 0.08
- female infertility due to zona pellucida defect · score 0.08
- oocyte maturation defect 11 · score 0.08
- Hydatidiform Mole · score 0.08
- oocyte/zygote/embryo maturation arrest 17 · score 0.07
- premature ovarian failure 19 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NDY0-F1 | alphafold | PREDICTED | 66.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NDY0.
Amino-acid sequence (278 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PABPN1L?
The strongest Open Targets associations for PABPN1L are neurodegenerative disease, mean platelet volume, Female infertility due to fertilization defect, Rare genetic female infertility and female infertility due to oocyte meiotic arrest.
How long is the PABPN1L protein?
The Homo sapiens PABPN1L protein (UniProt A6NDY0) is 278 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NDY0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NDY0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.