Pleckstrin homology domain-containing family D member 1 (PLEKHD1)
Homo sapiens — UniProt A6NEE1
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family D member 1 (PLEKHD1) is a protein from Homo sapiens identified by UniProt accession A6NEE1, 506 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: A6NEE1; gene symbol PLEKHD1.
- Organism: Homo sapiens.
- Length: 506 amino acids.
- Top disease associations (Open Targets): alkaline phosphatase measurement, neurodegenerative disease and IGF-1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family D member 1 |
|---|---|
| UniProt accession | A6NEE1 |
| Gene | PLEKHD1 |
| Organism | Homo sapiens |
| Length | 506 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.31
- neurodegenerative disease · score 0.18
- IGF-1 measurement · score 0.10
- facial asymmetry measurement · score 0.07
- neutrophil count · score 0.06
- leukocyte count · score 0.06
- metabolite measurement · score 0.04
- neutrophil percentage of leukocytes · score 0.03
- hair shape measurement · score 0.03
- myeloid white cell count · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NEE1-F1 | alphafold | PREDICTED | 81.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NEE1.
Amino-acid sequence (506 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHD1?
The strongest Open Targets associations for PLEKHD1 are alkaline phosphatase measurement, neurodegenerative disease, IGF-1 measurement, facial asymmetry measurement and neutrophil count.
How long is the PLEKHD1 protein?
The Homo sapiens PLEKHD1 protein (UniProt A6NEE1) is 506 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NEE1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NEE1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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