Arrestin domain-containing protein 5 (ARRDC5)
Homo sapiens — UniProt A6NEK1
Data last refreshed: (UniProt release unknown)
Key facts
Arrestin domain-containing protein 5 (ARRDC5) is a protein from Homo sapiens identified by UniProt accession A6NEK1, 328 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.
- UniProt accession: A6NEK1; gene symbol ARRDC5.
- Organism: Homo sapiens.
- Length: 328 amino acids.
- Top disease associations (Open Targets): body height, Agents acting on the renin-angiotensin system use measurement and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Arrestin domain-containing protein 5 |
|---|---|
| UniProt accession | A6NEK1 |
| Gene | ARRDC5 |
| Organism | Homo sapiens |
| Length | 328 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (145)
Diseases linked to this target (Open Targets).
- body height · score 0.15
- Agents acting on the renin-angiotensin system use measurement · score 0.13
- appendicular lean mass · score 0.11
- azoospermia · score 0.10
- lean body mass · score 0.10
- systolic blood pressure · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- refractive error measurement · score 0.09
- cortical surface area measurement · score 0.08
- birth weight · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NEK1-F1 | alphafold | PREDICTED | 84.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NEK1.
Amino-acid sequence (328 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARRDC5?
The strongest Open Targets associations for ARRDC5 are body height, Agents acting on the renin-angiotensin system use measurement, appendicular lean mass, azoospermia and lean body mass.
How long is the ARRDC5 protein?
The Homo sapiens ARRDC5 protein (UniProt A6NEK1) is 328 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NEK1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NEK1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.