Single-pass membrane and coiled-coil domain-containing protein 2 (SMCO2)
Homo sapiens — UniProt A6NFE2
Data last refreshed: (UniProt release unknown)
Key facts
Single-pass membrane and coiled-coil domain-containing protein 2 (SMCO2) is a protein from Homo sapiens identified by UniProt accession A6NFE2, 343 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.
- UniProt accession: A6NFE2; gene symbol SMCO2.
- Organism: Homo sapiens.
- Length: 343 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, papillary thyroid carcinoma and systemic lupus erythematosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Single-pass membrane and coiled-coil domain-containing protein 2 |
|---|---|
| UniProt accession | A6NFE2 |
| Gene | SMCO2 |
| Organism | Homo sapiens |
| Length | 343 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (5)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.01
- papillary thyroid carcinoma · score 0.00
- systemic lupus erythematosus · score 0.00
- neoplasm · score 0.00
- male infertility · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NFE2-F1 | alphafold | PREDICTED | 59.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NFE2.
Amino-acid sequence (343 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMCO2?
The strongest Open Targets associations for SMCO2 are lung adenocarcinoma, papillary thyroid carcinoma, systemic lupus erythematosus, neoplasm and male infertility.
How long is the SMCO2 protein?
The Homo sapiens SMCO2 protein (UniProt A6NFE2) is 343 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NFE2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NFE2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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