Transmembrane protein 221 (TMEM221)
Homo sapiens — UniProt A6NGB7
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 221 (TMEM221) is a protein from Homo sapiens identified by UniProt accession A6NGB7, 291 residues long. MolForge cross-references it against 0 known binders and 3 disease associations.
- UniProt accession: A6NGB7; gene symbol TMEM221.
- Organism: Homo sapiens.
- Length: 291 amino acids.
- Top disease associations (Open Targets): creatinine measurement, HbA1c measurement and reticulocyte measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 221 |
|---|---|
| UniProt accession | A6NGB7 |
| Gene | TMEM221 |
| Organism | Homo sapiens |
| Length | 291 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (3)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.03
- HbA1c measurement · score 0.02
- reticulocyte measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NGB7-F1 | alphafold | PREDICTED | 68.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NGB7.
Amino-acid sequence (291 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM221?
The strongest Open Targets associations for TMEM221 are creatinine measurement, HbA1c measurement and reticulocyte measurement.
How long is the TMEM221 protein?
The Homo sapiens TMEM221 protein (UniProt A6NGB7) is 291 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NGB7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NGB7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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