About Photoreceptor cilium actin regulator
Photoreceptor cilium actin regulator (PCARE) is a protein
from Homo sapiens identified by UniProt accession
A6NGG8, 1288 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Photoreceptor cilium actin regulator |
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| UniProt accession | A6NGG8 |
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| Gene | PCARE |
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| Organism | Homo sapiens |
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| Length | 1288 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (133)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.72
- Retinal dystrophy · score 0.55
- autosomal recessive retinitis pigmentosa · score 0.49
- PCARE-related retinopathy · score 0.45
- Cone rod dystrophy · score 0.44
- cone-rod dystrophy · score 0.42
- Stargardt disease · score 0.35
- genetic disorder · score 0.19
- Posterior column ataxia - retinitis pigmentosa · score 0.17
- neurofibrillary tangles measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NGG8-F1 | alphafold | PREDICTED | 43.77 | — |
Amino-acid sequence (1288 residues)
MGCTPSHSDL VNSVAKSGIQ FLKKPKAIRP GCQGGSERGS IPLLVKNSTC YDAGEGLAEE QPSPRRNQTT AKGLCQLMGD PASGKRKDME GLIPGTKTSS SQLNKSQSHM AKDIPFKTQG SHGSQGADFS GDESEESSTQ DTSKWKRTAK CHTSSTQSHC YQTIHPAHEP EGKVDFPEPL VKAHQQAYTY LHSSLSKYEA ILCIIHQATQ TRELLQPMVS FLLLCFEEIS QLLGEISKDG EVLLQEVRED LAWPLKKREP QEQPNLLQQL LQYTVSKLQV LNGTVASLTG SFLEGSSSYL HSTATHLENK LSTKRNVDER LLRALRQLES LASGCGDPGV QGLPLCSEDS GIGADNESVQ SVDKLGKQTS WDLAPEPEEW KSVTSPHTEA RQSGHTWQQS PFCLGSGRPQ DCLLSGAPMA KVQPRAQDEA RSPCLSSTSP ENITSPPLKL GTSTPCDSFG IGVSVEPHLS KTSRPMDASS LSDSEDSSPE EEEEDKMSSM SLCAWQEKTP HSRPQSSPAD RESPFQARTR RLRSLQAQEM ILKMKESISE RIKFVPVPCG HQDWSEEEEG RTVVPPRPST VSGSRRAPER QTRSQSESCL QSHVEDPTFQ ELRRVQRDLS QKLEAFYALG AKGQGQSQEQ ILQPRAAAVW PNGTCRVSPS NTTSRLKASL TKNFSILPSQ DKSILQKCNP HPEDEQGKAG KLPNAIPSGE VSEAAKATDW NVRGCPTRTS VKKLIETFSP TESLRMLGDS KDAGASPCLR NCIMPPRFPK YTGLAPLYPK PQISPASGRE SLKMGIGWKP LAPIFPPLPK AEAAKSEELS CEMEGNLEHL PPPPMEVLMD KSFASLESPE SSKSTENSPK ETQEPGPGEA GPTRRTWASP KLRASVSPLD LLPSKSTASL TKPHSTGPGS GRSSCQPRKP ALDLSSPPAT SQSPEVKGGT WSQAEKATSL YRQPRKAIAW HHSGPPSGQN RTSESSLARP RQSRERSPPV GRKASPTRTH WVPQADKRRR SLPSSYRPAQ PSPSAVQTPP SPPVSPRVLS PPTTKRRTSP PHQPKLPNPP PESAPAQCKV PSPPTQHPEA SPPFSIPSPS PPMSPSQEHK ETRDSEDSQA VIAKVSGNTH SIFCPATSSL FEAKPPLSTA HPLTPPSLPP EAGGPLGNPA ECWKNSSGPW LRADSQRRAA LCALNPLPFL RRTASDRQPG GRPQPPTLDP TSTSYESQLG QNSSSEESPK KDTEPGSSPC SPELQGGTRR ASPPEFCVLG HGLQPEPRTG HIQDKSQPEA QPQQEEVS
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