Photoreceptor cilium actin regulator (PCARE)
Homo sapiens — UniProt A6NGG8
Data last refreshed: (UniProt release unknown)
Key facts
Photoreceptor cilium actin regulator (PCARE) is a protein from Homo sapiens identified by UniProt accession A6NGG8, 1288 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.
- UniProt accession: A6NGG8; gene symbol PCARE.
- Organism: Homo sapiens.
- Length: 1288 amino acids.
- Top disease associations (Open Targets): retinitis pigmentosa, Retinal dystrophy and autosomal recessive retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Photoreceptor cilium actin regulator |
|---|---|
| UniProt accession | A6NGG8 |
| Gene | PCARE |
| Organism | Homo sapiens |
| Length | 1288 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (133)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.72
- Retinal dystrophy · score 0.55
- autosomal recessive retinitis pigmentosa · score 0.49
- PCARE-related retinopathy · score 0.45
- Cone rod dystrophy · score 0.44
- cone-rod dystrophy · score 0.42
- Stargardt disease · score 0.35
- genetic disorder · score 0.19
- Posterior column ataxia - retinitis pigmentosa · score 0.17
- neurofibrillary tangles measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NGG8-F1 | alphafold | PREDICTED | 43.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NGG8.
Amino-acid sequence (1288 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCARE?
The strongest Open Targets associations for PCARE are retinitis pigmentosa, Retinal dystrophy, autosomal recessive retinitis pigmentosa, PCARE-related retinopathy and Cone rod dystrophy.
How long is the PCARE protein?
The Homo sapiens PCARE protein (UniProt A6NGG8) is 1288 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NGG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NGG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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