About Coiled-coil domain-containing protein 154
Coiled-coil domain-containing protein 154 (CCDC154) is a protein
from Homo sapiens identified by UniProt accession
A6NI56, 667 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (56)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.26
- reticulocyte measurement · score 0.15
- monocyte count · score 0.06
- tricho-dento-osseous syndrome · score 0.05
- Autosomal recessive malignant osteopetrosis · score 0.05
- autosomal dominant osteosclerosis, Worth type · score 0.05
- heel bone mineral density · score 0.04
- dentin dysplasia · score 0.04
- dentin dysplasia-sclerotic bones syndrome · score 0.04
- Dentin dysplasia - sclerotic bones · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for A6NI56.
Amino-acid sequence (667 residues)
MSELADSGPS GASAPSQLRA VTLEDLGLLL AGGLASPEPL SLEELSERYE SSHPTSTASV PEQDTAKHWN QLEQWVVELQ AEVACLREHK QRCERATRSL LRELLQVRAR VQLQGSELRQ LQQEARPAAQ APEKEAPEFS GLQNQMQALD KRLVEVREAL TRLRRRQVQQ EAERRGAEQE AGLRLAKLTD LLQQEEQGRE VACGALQKNQ EDSSRRVDLE VARMQAQVTK LGEEVSLRFL KREAKLCGFL QKSFLALEKR MKASESSRLK LEGSLRGELE SRWEKLRGLM EERLRALQGQ HEESHLLEQC QGLDAAVAQL TKFVQQNQAS LNRVLLAEEK AWDAKGRLEE SRAGELAAYV QENLEAAQLA GELARQEMHG ELVLLREKSR ALEASVAQLA GQLKELSGHL PALSSRLDLQ EQMLGLRLSE AKTEWEGAER KSLEDLARWR KEVTEHLRGV REKVDGLPQQ IESVSDKCLL HKSDSDLRIS AEGKAREFKV GALRQELATL LSSVQLLKED NPGRKIAEMQ GKLATFQNQI MKLENCVQAN KTIQNLRFNT EARLRTQEMA TLWESVLRLW SEEGPRTPLG SWKALPSLVR PRVFIKDMAP GKVVPMNCWG VYQAVRWLRW KASLIKLRAL RRPGGVLEKP HSQEQVQQLT PSLFIQK
Explore Coiled-coil domain-containing protein 154 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets