Protein unc-119 homolog B (UNC119B)
Homo sapiens — UniProt A6NIH7
Data last refreshed: (UniProt release unknown)
Key facts
Protein unc-119 homolog B (UNC119B) is a protein from Homo sapiens identified by UniProt accession A6NIH7, 251 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: A6NIH7; gene symbol UNC119B.
- Organism: Homo sapiens.
- Length: 251 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein unc-119 homolog B |
|---|---|
| UniProt accession | A6NIH7 |
| Gene | UNC119B |
| Organism | Homo sapiens |
| Length | 251 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- mean corpuscular volume · score 0.39
- Red cell distribution width · score 0.38
- mean corpuscular hemoglobin concentration · score 0.34
- mean corpuscular hemoglobin · score 0.34
- erythrocyte count · score 0.33
- red blood cell density measurement · score 0.27
- metabolite measurement · score 0.26
- mean reticulocyte volume · score 0.26
- reticulocyte count · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NIH7-F1 | alphafold | PREDICTED | 79.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NIH7.
Amino-acid sequence (251 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UNC119B?
The strongest Open Targets associations for UNC119B are neurodegenerative disease, mean corpuscular volume, Red cell distribution width, mean corpuscular hemoglobin concentration and mean corpuscular hemoglobin.
How long is the UNC119B protein?
The Homo sapiens UNC119B protein (UniProt A6NIH7) is 251 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NIH7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NIH7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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