Leucine-rich repeat and IQ domain-containing protein 4 (LRRIQ4)
Homo sapiens — UniProt A6NIV6
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and IQ domain-containing protein 4 (LRRIQ4) is a protein from Homo sapiens identified by UniProt accession A6NIV6, 560 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: A6NIV6; gene symbol LRRIQ4.
- Organism: Homo sapiens.
- Length: 560 amino acids.
- Top disease associations (Open Targets): monocyte percentage of leukocytes, multiple sclerosis and renal cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and IQ domain-containing protein 4 |
|---|---|
| UniProt accession | A6NIV6 |
| Gene | LRRIQ4 |
| Organism | Homo sapiens |
| Length | 560 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- monocyte percentage of leukocytes · score 0.20
- multiple sclerosis · score 0.16
- renal cell carcinoma · score 0.15
- mean corpuscular hemoglobin · score 0.15
- central nervous system cancer · score 0.11
- mean corpuscular volume · score 0.11
- erythrocyte count · score 0.06
- mean corpuscular hemoglobin concentration · score 0.05
- Barrett's esophagus · score 0.04
- red blood cell density measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NIV6-F1 | alphafold | PREDICTED | 89.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NIV6.
Amino-acid sequence (560 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRIQ4?
The strongest Open Targets associations for LRRIQ4 are monocyte percentage of leukocytes, multiple sclerosis, renal cell carcinoma, mean corpuscular hemoglobin and central nervous system cancer.
How long is the LRRIQ4 protein?
The Homo sapiens LRRIQ4 protein (UniProt A6NIV6) is 560 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NIV6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NIV6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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