Transmembrane protein 278 (TMEM278)
Homo sapiens — UniProt A6NKF7
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 278 (TMEM278) is a protein from Homo sapiens identified by UniProt accession A6NKF7, 163 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: A6NKF7; gene symbol TMEM278.
- Organism: Homo sapiens.
- Length: 163 amino acids.
- Top disease associations (Open Targets): body height, 46,XY complete gonadal dysgenesis and Testicular regression syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 278 |
|---|---|
| UniProt accession | A6NKF7 |
| Gene | TMEM278 |
| Organism | Homo sapiens |
| Length | 163 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- body height · score 0.08
- 46,XY complete gonadal dysgenesis · score 0.05
- Testicular regression syndrome · score 0.04
- isolated congenital hypogonadotropic hypogonadism · score 0.04
- refractive error measurement · score 0.04
- 46,XX ovotesticular disorder of sex development · score 0.04
- von Willebrand factor measurement · score 0.04
- spermatogenic failure, X-linked, 2 · score 0.03
- Isolated follicle stimulating hormone deficiency · score 0.03
- papillary thyroid carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NKF7-F1 | alphafold | PREDICTED | 66.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NKF7.
Amino-acid sequence (163 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM278?
The strongest Open Targets associations for TMEM278 are body height, 46,XY complete gonadal dysgenesis, Testicular regression syndrome, isolated congenital hypogonadotropic hypogonadism and refractive error measurement.
How long is the TMEM278 protein?
The Homo sapiens TMEM278 protein (UniProt A6NKF7) is 163 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NKF7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NKF7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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