Choriogonadotropin subunit beta variant 1 (CGB1)
Homo sapiens — UniProt A6NKQ9
Data last refreshed: (UniProt release unknown)
Key facts
Choriogonadotropin subunit beta variant 1 (CGB1) is a protein from Homo sapiens identified by UniProt accession A6NKQ9, 187 residues long. MolForge cross-references it against 0 known binders and 279 disease associations.
- UniProt accession: A6NKQ9; gene symbol CGB1.
- Organism: Homo sapiens.
- Length: 187 amino acids.
- Top disease associations (Open Targets): testosterone measurement, Kallmann syndrome and isolated congenital hypogonadotropic hypogonadism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Choriogonadotropin subunit beta variant 1 |
|---|---|
| UniProt accession | A6NKQ9 |
| Gene | CGB1 |
| Organism | Homo sapiens |
| Length | 187 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (279)
Diseases linked to this target (Open Targets).
- testosterone measurement · score 0.16
- Kallmann syndrome · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.07
- 46,XX gonadal dysgenesis · score 0.07
- azoospermia · score 0.07
- hypogonadotropic hypogonadism · score 0.07
- primary ovarian insufficiency · score 0.07
- Testicular regression syndrome · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
- partial androgen insensitivity syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NKQ9-F1 | alphafold | PREDICTED | 74.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NKQ9.
Amino-acid sequence (187 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CGB1?
The strongest Open Targets associations for CGB1 are testosterone measurement, Kallmann syndrome, isolated congenital hypogonadotropic hypogonadism, 46,XX gonadal dysgenesis and azoospermia.
How long is the CGB1 protein?
The Homo sapiens CGB1 protein (UniProt A6NKQ9) is 187 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NKQ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NKQ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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