Small integral membrane protein 23 (SMIM23)
Homo sapiens — UniProt A6NLE4
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 23 (SMIM23) is a protein from Homo sapiens identified by UniProt accession A6NLE4, 172 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: A6NLE4; gene symbol SMIM23.
- Organism: Homo sapiens.
- Length: 172 amino acids.
- Top disease associations (Open Targets): body height, lean body mass and forced expiratory volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 23 |
|---|---|
| UniProt accession | A6NLE4 |
| Gene | SMIM23 |
| Organism | Homo sapiens |
| Length | 172 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- body height · score 0.45
- lean body mass · score 0.41
- forced expiratory volume · score 0.40
- fat body mass · score 0.37
- appendicular lean mass · score 0.37
- vital capacity · score 0.34
- grip strength measurement · score 0.31
- cortical surface area measurement · score 0.31
- sitting height measurement · score 0.29
- facial morphology measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NLE4-F1 | alphafold | PREDICTED | 64.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NLE4.
Amino-acid sequence (172 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM23?
The strongest Open Targets associations for SMIM23 are body height, lean body mass, forced expiratory volume, fat body mass and appendicular lean mass.
How long is the SMIM23 protein?
The Homo sapiens SMIM23 protein (UniProt A6NLE4) is 172 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NLE4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NLE4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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