About Tripartite motif-containing protein 64C
Tripartite motif-containing protein 64C (TRIM64C) is a protein
from Homo sapiens identified by UniProt accession
A6NLI5, 450 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Tripartite motif-containing protein 64C |
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| UniProt accession | A6NLI5 |
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| Gene | TRIM64C |
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| Organism | Homo sapiens |
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| Length | 450 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.28
- systolic blood pressure · score 0.26
- alcohol consumption measurement · score 0.19
- hypertension · score 0.18
- physical activity · score 0.16
- HDL cholesterol change measurement · score 0.16
- urinary metabolite measurement · score 0.15
- intraocular pressure measurement · score 0.14
- blood protein measurement · score 0.13
- Agents acting on the renin-angiotensin system use measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NLI5-F1 | alphafold | PREDICTED | 83.68 | — |
Amino-acid sequence (450 residues)
MDSDTLRVFQ NELICCICVN YFIDPVTTDC VHSFCRPCLC LCSEEGRAPM RCPLCRKISE KPNFNTNVAL KKLASLARQT RPQNINSSDN ICVLHEETKE LFCEADKRLL CGPCSESPEH MAHSHSPIGW AAEECRVQKL IKEMDYLWKI NQETQNNLNQ ETSKFCSLVD YVSLRKVIIT IQYQKMHIFL DEEEQRHLQA LEREAKELFQ QLQDSQVRMT QHLEGMKDMY RELWETYHMP DVELLQDVGN ISARTDLAQM PKPQPVNPEL TSWCITGVLD MLNNFRVDNA LSTEMTPCYI SLSEDVRRVI FGDDHRSAPM DPQGVESFAV WCAQAFTSGK HYWEVDVTHS SNWILGVCRD SRTADTNIVI DSDKTFFSIS SKTSNHYSLS TNSPPLIQYV QRPLGWVGVF LDYDNGSVSF FDVSKGSLIY GFPPSSFSSP LRPFFCFGCT
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