C2 calcium-dependent domain-containing protein 4B (C2CD4B)
Homo sapiens — UniProt A6NLJ0
Data last refreshed: (UniProt release unknown)
Key facts
C2 calcium-dependent domain-containing protein 4B (C2CD4B) is a protein from Homo sapiens identified by UniProt accession A6NLJ0, 364 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.
- UniProt accession: A6NLJ0; gene symbol C2CD4B.
- Organism: Homo sapiens.
- Length: 364 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, waist-hip ratio and IGF-1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | C2 calcium-dependent domain-containing protein 4B |
|---|---|
| UniProt accession | A6NLJ0 |
| Gene | C2CD4B |
| Organism | Homo sapiens |
| Length | 364 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (99)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.39
- waist-hip ratio · score 0.35
- IGF-1 measurement · score 0.32
- von Willebrand factor measurement · score 0.30
- BMI-adjusted waist-hip ratio · score 0.28
- neurodegenerative disease · score 0.27
- PHF-tau measurement · score 0.24
- insulin measurement · score 0.23
- BMI-adjusted fasting blood glucose measurement · score 0.21
- Drugs used in diabetes use measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NLJ0-F1 | alphafold | PREDICTED | 59.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NLJ0.
Amino-acid sequence (364 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with C2CD4B?
The strongest Open Targets associations for C2CD4B are type 2 diabetes mellitus, waist-hip ratio, IGF-1 measurement, von Willebrand factor measurement and BMI-adjusted waist-hip ratio.
How long is the C2CD4B protein?
The Homo sapiens C2CD4B protein (UniProt A6NLJ0) is 364 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NLJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NLJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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