Double homeobox protein A (DUXA)
Homo sapiens — UniProt A6NLW8
Data last refreshed: (UniProt release unknown)
Key facts
Double homeobox protein A (DUXA) is a protein from Homo sapiens identified by UniProt accession A6NLW8, 204 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: A6NLW8; gene symbol DUXA.
- Organism: Homo sapiens.
- Length: 204 amino acids.
- Top disease associations (Open Targets): Dupuytren Contracture, Palmar Fibromatosis and Fasciitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Double homeobox protein A |
|---|---|
| UniProt accession | A6NLW8 |
| Gene | DUXA |
| Organism | Homo sapiens |
| Length | 204 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- Dupuytren Contracture · score 0.32
- Palmar Fibromatosis · score 0.31
- Fasciitis · score 0.25
- fibroblastic disorder · score 0.25
- neurodegenerative disease · score 0.21
- genetic disorder · score 0.12
- gut microbiome measurement · score 0.07
- triglyceride measurement · score 0.04
- high density lipoprotein cholesterol measurement · score 0.04
- non-small cell lung carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NLW8-F1 | alphafold | PREDICTED | 75.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NLW8.
Amino-acid sequence (204 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DUXA?
The strongest Open Targets associations for DUXA are Dupuytren Contracture, Palmar Fibromatosis, Fasciitis, fibroblastic disorder and neurodegenerative disease.
How long is the DUXA protein?
The Homo sapiens DUXA protein (UniProt A6NLW8) is 204 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NLW8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NLW8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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