Leucine-rich repeat-containing protein 53 (LRRC53)
Homo sapiens — UniProt A6NM62
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 53 (LRRC53) is a protein from Homo sapiens identified by UniProt accession A6NM62, 1247 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: A6NM62; gene symbol LRRC53.
- Organism: Homo sapiens.
- Length: 1247 amino acids.
- Top disease associations (Open Targets): atrial conduction disease, body mass index and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 53 |
|---|---|
| UniProt accession | A6NM62 |
| Gene | LRRC53 |
| Organism | Homo sapiens |
| Length | 1247 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- atrial conduction disease · score 0.45
- body mass index · score 0.28
- lean body mass · score 0.27
- physical activity measurement · score 0.26
- obesity · score 0.26
- fat body mass · score 0.24
- smoking initiation · score 0.24
- age at menarche · score 0.24
- smoking status measurement · score 0.23
- smoking behavior · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NM62-F1 | alphafold | PREDICTED | 44.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NM62.
Amino-acid sequence (1247 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC53?
The strongest Open Targets associations for LRRC53 are atrial conduction disease, body mass index, lean body mass, physical activity measurement and obesity.
How long is the LRRC53 protein?
The Homo sapiens LRRC53 protein (UniProt A6NM62) is 1247 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NM62 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NM62 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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