Transmembrane protein 212 (TMEM212)
Homo sapiens — UniProt A6NML5
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 212 (TMEM212) is a protein from Homo sapiens identified by UniProt accession A6NML5, 194 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: A6NML5; gene symbol TMEM212.
- Organism: Homo sapiens.
- Length: 194 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, intraocular pressure measurement and corneal resistance factor.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 212 |
|---|---|
| UniProt accession | A6NML5 |
| Gene | TMEM212 |
| Organism | Homo sapiens |
| Length | 194 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.39
- intraocular pressure measurement · score 0.38
- corneal resistance factor · score 0.30
- sex hormone-binding globulin measurement · score 0.26
- mean corpuscular volume · score 0.12
- eosinophil count · score 0.07
- reticulocyte count · score 0.06
- HbA1c measurement · score 0.05
- primary familial polycythemia due to EPO receptor mutation · score 0.05
- essential thrombocythemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NML5-F1 | alphafold | PREDICTED | 74.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NML5.
Amino-acid sequence (194 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM212?
The strongest Open Targets associations for TMEM212 are Red cell distribution width, intraocular pressure measurement, corneal resistance factor, sex hormone-binding globulin measurement and mean corpuscular volume.
How long is the TMEM212 protein?
The Homo sapiens TMEM212 protein (UniProt A6NML5) is 194 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NML5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NML5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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