Eukaryotic translation initiation factor 4E type 1B (EIF4E1B)
Homo sapiens — UniProt A6NMX2
Data last refreshed: (UniProt release unknown)
Key facts
Eukaryotic translation initiation factor 4E type 1B (EIF4E1B) is a protein from Homo sapiens identified by UniProt accession A6NMX2, 242 residues long. MolForge cross-references it against 0 known binders and 6 disease associations.
- UniProt accession: A6NMX2; gene symbol EIF4E1B.
- Organism: Homo sapiens.
- Length: 242 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, central nervous system cancer and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Eukaryotic translation initiation factor 4E type 1B |
|---|---|
| UniProt accession | A6NMX2 |
| Gene | EIF4E1B |
| Organism | Homo sapiens |
| Length | 242 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (6)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- central nervous system cancer · score 0.04
- glioblastoma multiforme · score 0.03
- neoplasm · score 0.01
- cancer · score 0.01
- nonpapillary renal cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NMX2-F1 | alphafold | PREDICTED | 82.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NMX2.
Amino-acid sequence (242 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EIF4E1B?
The strongest Open Targets associations for EIF4E1B are neurodegenerative disease, central nervous system cancer, glioblastoma multiforme, neoplasm and cancer.
How long is the EIF4E1B protein?
The Homo sapiens EIF4E1B protein (UniProt A6NMX2) is 242 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NMX2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NMX2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.