E3 ubiquitin-protein ligase MARCHF11 (MARCHF11)
Homo sapiens — UniProt A6NNE9
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase MARCHF11 (MARCHF11) is a protein from Homo sapiens identified by UniProt accession A6NNE9, 402 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: A6NNE9; gene symbol MARCHF11.
- Organism: Homo sapiens.
- Length: 402 amino acids.
- Top disease associations (Open Targets): breast carcinoma, smoking status measurement and adolescent idiopathic scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase MARCHF11 |
|---|---|
| UniProt accession | A6NNE9 |
| Gene | MARCHF11 |
| Organism | Homo sapiens |
| Length | 402 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- breast carcinoma · score 0.35
- smoking status measurement · score 0.29
- adolescent idiopathic scoliosis · score 0.24
- reticulocyte count · score 0.13
- central nervous system cancer · score 0.04
- refractive error measurement · score 0.04
- hemorrhoid · score 0.03
- neuroimaging measurement · score 0.03
- glioblastoma multiforme · score 0.02
- brain measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NNE9-F1 | alphafold | PREDICTED | 62.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NNE9.
Amino-acid sequence (402 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MARCHF11?
The strongest Open Targets associations for MARCHF11 are breast carcinoma, smoking status measurement, adolescent idiopathic scoliosis, reticulocyte count and central nervous system cancer.
How long is the MARCHF11 protein?
The Homo sapiens MARCHF11 protein (UniProt A6NNE9) is 402 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NNE9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NNE9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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