Ubiquitin carboxyl-terminal hydrolase 27 (USP27X)
Homo sapiens — UniProt A6NNY8
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 27 (USP27X) is a protein from Homo sapiens identified by UniProt accession A6NNY8, 438 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: A6NNY8; gene symbol USP27X.
- Organism: Homo sapiens.
- Length: 438 amino acids.
- Top disease associations (Open Targets): X-linked non-syndromic intellectual disability, Intellectual disability and Neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 27 |
|---|---|
| UniProt accession | A6NNY8 |
| Gene | USP27X |
| Organism | Homo sapiens |
| Length | 438 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.65
- Intellectual disability · score 0.57
- Neurodevelopmental disorder · score 0.27
- X-linked intellectual disability · score 0.19
- genetic disorder · score 0.18
- hepatocellular carcinoma · score 0.09
- breast cancer · score 0.07
- neoplasm · score 0.06
- osteosarcoma · score 0.05
- cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A6NNY8-F1 | alphafold | PREDICTED | 78.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A6NNY8.
Amino-acid sequence (438 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP27X?
The strongest Open Targets associations for USP27X are X-linked non-syndromic intellectual disability, Intellectual disability, Neurodevelopmental disorder, X-linked intellectual disability and genetic disorder.
How long is the USP27X protein?
The Homo sapiens USP27X protein (UniProt A6NNY8) is 438 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A6NNY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A6NNY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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