Calcium-activated chloride channel regulator 1 (CLCA1)
Homo sapiens — UniProt A8K7I4
Data last refreshed: (UniProt release unknown)
Key facts
Calcium-activated chloride channel regulator 1 (CLCA1) is a protein from Homo sapiens identified by UniProt accession A8K7I4, 914 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.
- UniProt accession: A8K7I4; gene symbol CLCA1.
- Organism: Homo sapiens.
- Length: 914 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, breast adenocarcinoma and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium-activated chloride channel regulator 1 |
|---|---|
| UniProt accession | A8K7I4 |
| Gene | CLCA1 |
| Organism | Homo sapiens |
| Length | 914 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (121)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.12
- neoplasm · score 0.08
- chronic obstructive pulmonary disease · score 0.08
- body height · score 0.08
- Barrett's esophagus · score 0.08
- diabetes mellitus · score 0.07
- ulcerative colitis · score 0.06
- pulse pressure measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8K7I4-F1 | alphafold | PREDICTED | 88.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8K7I4.
Amino-acid sequence (914 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLCA1?
The strongest Open Targets associations for CLCA1 are glioblastoma multiforme, breast adenocarcinoma, head and neck squamous cell carcinoma, neoplasm and chronic obstructive pulmonary disease.
How long is the CLCA1 protein?
The Homo sapiens CLCA1 protein (UniProt A8K7I4) is 914 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8K7I4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8K7I4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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