Protein SFI1 homolog (SFI1)
Homo sapiens — UniProt A8K8P3
Data last refreshed: (UniProt release unknown)
Key facts
Protein SFI1 homolog (SFI1) is a protein from Homo sapiens identified by UniProt accession A8K8P3, 1242 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: A8K8P3; gene symbol SFI1.
- Organism: Homo sapiens.
- Length: 1242 amino acids.
- Top disease associations (Open Targets): Cleft palate, cleft lip and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein SFI1 homolog |
|---|---|
| UniProt accession | A8K8P3 |
| Gene | SFI1 |
| Organism | Homo sapiens |
| Length | 1242 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- Cleft palate · score 0.32
- cleft lip · score 0.32
- type 2 diabetes mellitus · score 0.28
- diastolic blood pressure · score 0.26
- low grade glioma · score 0.23
- ovarian cancer · score 0.23
- breast adenocarcinoma · score 0.23
- lymphocyte count · score 0.19
- reticulocyte count · score 0.14
- diet measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8K8P3-F1 | alphafold | PREDICTED | 66.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8K8P3.
Amino-acid sequence (1242 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SFI1?
The strongest Open Targets associations for SFI1 are Cleft palate, cleft lip, type 2 diabetes mellitus, diastolic blood pressure and low grade glioma.
How long is the SFI1 protein?
The Homo sapiens SFI1 protein (UniProt A8K8P3) is 1242 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8K8P3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8K8P3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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