Nuclear pore complex-interacting protein family member B5 (NPIPB5)
Homo sapiens — UniProt A8MRT5
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear pore complex-interacting protein family member B5 (NPIPB5) is a protein from Homo sapiens identified by UniProt accession A8MRT5, 1133 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: A8MRT5; gene symbol NPIPB5.
- Organism: Homo sapiens.
- Length: 1133 amino acids.
- Top disease associations (Open Targets): body weight, body height and nonpapillary renal cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear pore complex-interacting protein family member B5 |
|---|---|
| UniProt accession | A8MRT5 |
| Gene | NPIPB5 |
| Organism | Homo sapiens |
| Length | 1133 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- body weight · score 0.04
- body height · score 0.03
- nonpapillary renal cell carcinoma · score 0.01
- IGA glomerulonephritis · score 0.00
- Ataxia-telangiectasia · score 0.00
- adenoma · score 0.00
- cancer · score 0.00
- cardiovascular disease · score 0.00
- prostate carcinoma · score 0.00
- juvenile idiopathic arthritis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8MRT5-F1 | alphafold | PREDICTED | 44.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8MRT5.
Amino-acid sequence (1133 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NPIPB5?
The strongest Open Targets associations for NPIPB5 are body weight, body height, nonpapillary renal cell carcinoma, IGA glomerulonephritis and Ataxia-telangiectasia.
How long is the NPIPB5 protein?
The Homo sapiens NPIPB5 protein (UniProt A8MRT5) is 1133 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8MRT5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8MRT5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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