Forkhead box protein I3 (FOXI3)
Homo sapiens — UniProt A8MTJ6
Data last refreshed: (UniProt release unknown)
Key facts
Forkhead box protein I3 (FOXI3) is a protein from Homo sapiens identified by UniProt accession A8MTJ6, 420 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: A8MTJ6; gene symbol FOXI3.
- Organism: Homo sapiens.
- Length: 420 amino acids.
- Top disease associations (Open Targets): craniofacial microsomia, neurodegenerative disease and tooth agenesis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Forkhead box protein I3 |
|---|---|
| UniProt accession | A8MTJ6 |
| Gene | FOXI3 |
| Organism | Homo sapiens |
| Length | 420 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- craniofacial microsomia · score 0.41
- neurodegenerative disease · score 0.35
- tooth agenesis · score 0.25
- optic disc size measurement · score 0.24
- Aplasia/Hypoplasia of the thymus · score 0.18
- genetic disorder · score 0.18
- hair color · score 0.18
- visceral adipose tissue measurement · score 0.06
- non-small cell lung carcinoma · score 0.05
- thickened earlobes-conductive deafness syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8MTJ6-F1 | alphafold | PREDICTED | 57.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8MTJ6.
Amino-acid sequence (420 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FOXI3?
The strongest Open Targets associations for FOXI3 are craniofacial microsomia, neurodegenerative disease, tooth agenesis, optic disc size measurement and Aplasia/Hypoplasia of the thymus.
How long is the FOXI3 protein?
The Homo sapiens FOXI3 protein (UniProt A8MTJ6) is 420 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8MTJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8MTJ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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