Smoothelin-like protein 1 (SMTNL1)
Homo sapiens — UniProt A8MU46
Data last refreshed: (UniProt release unknown)
Key facts
Smoothelin-like protein 1 (SMTNL1) is a protein from Homo sapiens identified by UniProt accession A8MU46, 494 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: A8MU46; gene symbol SMTNL1.
- Organism: Homo sapiens.
- Length: 494 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist circumference, monocyte count and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Smoothelin-like protein 1 |
|---|---|
| UniProt accession | A8MU46 |
| Gene | SMTNL1 |
| Organism | Homo sapiens |
| Length | 494 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist circumference · score 0.18
- monocyte count · score 0.16
- mathematical ability · score 0.06
- plasma protease C1 inhibitor measurement · score 0.04
- Moyamoya disease · score 0.04
- familial cylindromatosis · score 0.03
- hyperthyroidism · score 0.03
- Capillary malformation - arteriovenous malformation · score 0.03
- systemic lupus erythematosus · score 0.02
- Dental malocclusion · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8MU46-F1 | alphafold | PREDICTED | 55.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8MU46.
Amino-acid sequence (494 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMTNL1?
The strongest Open Targets associations for SMTNL1 are BMI-adjusted waist circumference, monocyte count, mathematical ability, plasma protease C1 inhibitor measurement and Moyamoya disease.
How long is the SMTNL1 protein?
The Homo sapiens SMTNL1 protein (UniProt A8MU46) is 494 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8MU46 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8MU46 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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