Zinc finger protein 727 (ZNF727)
Homo sapiens — UniProt A8MUV8
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 727 (ZNF727) is a protein from Homo sapiens identified by UniProt accession A8MUV8, 499 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: A8MUV8; gene symbol ZNF727.
- Organism: Homo sapiens.
- Length: 499 amino acids.
- Top disease associations (Open Targets): triglyceride measurement, Cystic Kidney Disease and X-linked severe congenital neutropenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 727 |
|---|---|
| UniProt accession | A8MUV8 |
| Gene | ZNF727 |
| Organism | Homo sapiens |
| Length | 499 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.10
- Cystic Kidney Disease · score 0.07
- X-linked severe congenital neutropenia · score 0.04
- Blackfan-Diamond anemia · score 0.04
- eosinophil percentage of leukocytes · score 0.04
- neutropenia, severe congenital, 2, autosomal dominant · score 0.04
- nonimmune chronic idiopathic neutropenia of adults · score 0.04
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency · score 0.04
- reticular dysgenesis · score 0.04
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8MUV8-F1 | alphafold | PREDICTED | 69.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8MUV8.
Amino-acid sequence (499 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF727?
The strongest Open Targets associations for ZNF727 are triglyceride measurement, Cystic Kidney Disease, X-linked severe congenital neutropenia, Blackfan-Diamond anemia and eosinophil percentage of leukocytes.
How long is the ZNF727 protein?
The Homo sapiens ZNF727 protein (UniProt A8MUV8) is 499 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8MUV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8MUV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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