Serpin E3 (SERPINE3)

About Serpin E3

Serpin E3 (SERPINE3) is a protein from Homo sapiens identified by UniProt accession A8MV23, 424 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Serpin E3
UniProt accession	A8MV23
Gene	SERPINE3
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.49
neurodegenerative disease · score 0.17
optic cup area measurement · score 0.09
cup-to-disc ratio measurement · score 0.09
optic disc area measurement · score 0.09
Nasal Cavity Polyp · score 0.07
corneal topography · score 0.03
COVID-19 · score 0.03
alkaline phosphatase measurement · score 0.02
cancer · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MV23-F1	alphafold	PREDICTED	78.76	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8MV23.

Amino-acid sequence (424 residues)

MPPFLITLFL FHSCCLRANG HLREGMTLLK TEFALHLYQS VAACRNETNF VISPAGVSLP LEILQFGAEG STGQQLADAL GYTVHDKRVK DFLHAVYATL PTSSQGTEME LACSLFVQVG TPLSPCFVEH VSWWANSSLE PADLSEPNST AIQTSEGASR ETAGGGPSEG PGGWPWEQVS AAFAQLVLVS TMSFQGTWRK RFSSTDTQIL PFTCAYGLVL QVPMMHQTTE VNYGQFQDTA GHQVGVLELP YLGSAVSLFL VLPRDKDTPL SHIEPHLTAS TIHLWTTSLR RARMDVFLPR FRIQNQFNLK SILNSWGVTD LFDPLKANLK GISGQDGFYV SEAIHKAKIE VLEEGTKASG ATALLLLKRS RIPIFKADRP FIYFLREPNT GITVFFDRIQ IIYQCLSSNK GSFVHYPLKN KHSF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards