Transcription cofactor vestigial-like protein 3 (VGLL3)
Homo sapiens — UniProt A8MV65
Data last refreshed: (UniProt release unknown)
Key facts
Transcription cofactor vestigial-like protein 3 (VGLL3) is a protein from Homo sapiens identified by UniProt accession A8MV65, 326 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.
- UniProt accession: A8MV65; gene symbol VGLL3.
- Organism: Homo sapiens.
- Length: 326 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, triglyceride measurement and prostate carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription cofactor vestigial-like protein 3 |
|---|---|
| UniProt accession | A8MV65 |
| Gene | VGLL3 |
| Organism | Homo sapiens |
| Length | 326 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- triglyceride measurement · score 0.44
- prostate carcinoma · score 0.42
- high density lipoprotein cholesterol measurement · score 0.38
- age at menarche · score 0.38
- sex hormone-binding globulin measurement · score 0.37
- type 2 diabetes mellitus · score 0.31
- breast carcinoma · score 0.31
- monocyte count · score 0.31
- BMI-adjusted hip circumference · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8MV65-F1 | alphafold | PREDICTED | 55.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8MV65.
Amino-acid sequence (326 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VGLL3?
The strongest Open Targets associations for VGLL3 are neurodegenerative disease, triglyceride measurement, prostate carcinoma, high density lipoprotein cholesterol measurement and age at menarche.
How long is the VGLL3 protein?
The Homo sapiens VGLL3 protein (UniProt A8MV65) is 326 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8MV65 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8MV65 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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