Rho guanine nucleotide exchange factor 33 (ARHGEF33)
Homo sapiens — UniProt A8MVX0
Data last refreshed: (UniProt release unknown)
Key facts
Rho guanine nucleotide exchange factor 33 (ARHGEF33) is a protein from Homo sapiens identified by UniProt accession A8MVX0, 844 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: A8MVX0; gene symbol ARHGEF33.
- Organism: Homo sapiens.
- Length: 844 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, birth weight and sex hormone-binding globulin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 33 |
|---|---|
| UniProt accession | A8MVX0 |
| Gene | ARHGEF33 |
| Organism | Homo sapiens |
| Length | 844 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- birth weight · score 0.17
- sex hormone-binding globulin measurement · score 0.09
- cystatin C measurement · score 0.07
- Young adult-onset Parkinsonism · score 0.05
- essential tremor · score 0.05
- torsion dystonia 2 · score 0.05
- Spinocerebellar ataxia type 40 · score 0.05
- attention deficit hyperactivity disorder · score 0.05
- spinocerebellar ataxia type 20 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8MVX0-F1 | alphafold | PREDICTED | 55.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8MVX0.
Amino-acid sequence (844 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGEF33?
The strongest Open Targets associations for ARHGEF33 are breast adenocarcinoma, birth weight, sex hormone-binding globulin measurement, cystatin C measurement and Young adult-onset Parkinsonism.
How long is the ARHGEF33 protein?
The Homo sapiens ARHGEF33 protein (UniProt A8MVX0) is 844 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8MVX0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8MVX0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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