Small integral membrane protein 34 (SMIM34)
Homo sapiens — UniProt A8MWV9
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 34 (SMIM34) is a protein from Homo sapiens identified by UniProt accession A8MWV9, 139 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: A8MWV9; gene symbol SMIM34.
- Organism: Homo sapiens.
- Length: 139 amino acids.
- Top disease associations (Open Targets): electrocardiography, QT interval and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 34 |
|---|---|
| UniProt accession | A8MWV9 |
| Gene | SMIM34 |
| Organism | Homo sapiens |
| Length | 139 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.23
- QT interval · score 0.15
- FEV/FVC ratio · score 0.10
- myocardial infarction · score 0.10
- BMI-adjusted waist-hip ratio · score 0.09
- angina pectoris · score 0.09
- PHF-tau measurement · score 0.09
- coronary artery disease · score 0.08
- BMI-adjusted waist circumference · score 0.08
- pulmonary function measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A8MWV9-F1 | alphafold | PREDICTED | 60.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A8MWV9.
Amino-acid sequence (139 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM34?
The strongest Open Targets associations for SMIM34 are electrocardiography, QT interval, FEV/FVC ratio, myocardial infarction and BMI-adjusted waist-hip ratio.
How long is the SMIM34 protein?
The Homo sapiens SMIM34 protein (UniProt A8MWV9) is 139 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A8MWV9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A8MWV9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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