Isthmin-1 (ISM1)
Homo sapiens — UniProt B1AKI9
Data last refreshed: (UniProt release unknown)
Key facts
Isthmin-1 (ISM1) is a protein from Homo sapiens identified by UniProt accession B1AKI9, 464 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.
- UniProt accession: B1AKI9; gene symbol ISM1.
- Organism: Homo sapiens.
- Length: 464 amino acids.
- Top disease associations (Open Targets): body height, balding measurement and hair shape measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Isthmin-1 |
|---|---|
| UniProt accession | B1AKI9 |
| Gene | ISM1 |
| Organism | Homo sapiens |
| Length | 464 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (121)
Diseases linked to this target (Open Targets).
- body height · score 0.42
- balding measurement · score 0.41
- hair shape measurement · score 0.32
- malnutrition · score 0.32
- nutritional deficiency disease · score 0.32
- appendicular lean mass · score 0.30
- neurodegenerative disease · score 0.27
- grip strength measurement · score 0.26
- drug use measurement · score 0.15
- type 2 diabetes mellitus · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-B1AKI9-F1 | alphafold | PREDICTED | 64.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for B1AKI9.
Amino-acid sequence (464 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ISM1?
The strongest Open Targets associations for ISM1 are body height, balding measurement, hair shape measurement, malnutrition and nutritional deficiency disease.
How long is the ISM1 protein?
The Homo sapiens ISM1 protein (UniProt B1AKI9) is 464 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB B1AKI9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB B1AKI9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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