Small integral membrane protein 1 (SMIM1)
Homo sapiens — UniProt B2RUZ4
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 1 (SMIM1) is a protein from Homo sapiens identified by UniProt accession B2RUZ4, 78 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: B2RUZ4; gene symbol SMIM1.
- Organism: Homo sapiens.
- Length: 78 amino acids.
- Top disease associations (Open Targets): reticulocyte count, reticulocyte measurement and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 1 |
|---|---|
| UniProt accession | B2RUZ4 |
| Gene | SMIM1 |
| Organism | Homo sapiens |
| Length | 78 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.56
- reticulocyte measurement · score 0.54
- Red cell distribution width · score 0.51
- mean corpuscular hemoglobin concentration · score 0.40
- hemoglobin measurement · score 0.39
- erythrocyte count · score 0.38
- mean corpuscular volume · score 0.37
- Immature Reticulocyte Fraction Measurement · score 0.32
- red blood cell density measurement · score 0.30
- HbA1c measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-B2RUZ4-F1 | alphafold | PREDICTED | 70.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for B2RUZ4.
Amino-acid sequence (78 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM1?
The strongest Open Targets associations for SMIM1 are reticulocyte count, reticulocyte measurement, Red cell distribution width, mean corpuscular hemoglobin concentration and hemoglobin measurement.
How long is the SMIM1 protein?
The Homo sapiens SMIM1 protein (UniProt B2RUZ4) is 78 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB B2RUZ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB B2RUZ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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