Golgi pH regulator A (GPR89A)
Homo sapiens — UniProt B7ZAQ6
Data last refreshed: (UniProt release unknown)
Key facts
Golgi pH regulator A (GPR89A) is a protein from Homo sapiens identified by UniProt accession B7ZAQ6, 455 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: B7ZAQ6; gene symbol GPR89A.
- Organism: Homo sapiens.
- Length: 455 amino acids.
- Top disease associations (Open Targets): Okt4 epitope deficiency, combined immunodeficiency with skin granulomas and 22q11.2 deletion syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Golgi pH regulator A |
|---|---|
| UniProt accession | B7ZAQ6 |
| Gene | GPR89A |
| Organism | Homo sapiens |
| Length | 455 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- Okt4 epitope deficiency · score 0.05
- combined immunodeficiency with skin granulomas · score 0.03
- 22q11.2 deletion syndrome · score 0.03
- X-Linked Combined Immunodeficiency Diseases · score 0.03
- Alymphoid cystic thymic dysgenesis · score 0.03
- immunodeficiency 19 · score 0.03
- immunodeficiency 18 · score 0.03
- uric acid measurement · score 0.03
- urate measurement · score 0.02
- Thrombocytopenia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-B7ZAQ6-F1 | alphafold | PREDICTED | 82.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for B7ZAQ6.
Amino-acid sequence (455 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR89A?
The strongest Open Targets associations for GPR89A are Okt4 epitope deficiency, combined immunodeficiency with skin granulomas, 22q11.2 deletion syndrome, X-Linked Combined Immunodeficiency Diseases and Alymphoid cystic thymic dysgenesis.
How long is the GPR89A protein?
The Homo sapiens GPR89A protein (UniProt B7ZAQ6) is 455 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB B7ZAQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB B7ZAQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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