Protein Frey 1 (FREY1)
Homo sapiens — UniProt C9JXX5
Data last refreshed: (UniProt release unknown)
Key facts
Protein Frey 1 (FREY1) is a protein from Homo sapiens identified by UniProt accession C9JXX5, 98 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.
- UniProt accession: C9JXX5; gene symbol FREY1.
- Organism: Homo sapiens.
- Length: 98 amino acids.
- Top disease associations (Open Targets): azoospermia, Male infertility with spermatogenesis disorder due to single gene mutation and Rare genetic female infertility.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein Frey 1 |
|---|---|
| UniProt accession | C9JXX5 |
| Gene | FREY1 |
| Organism | Homo sapiens |
| Length | 98 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (101)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
- Rare genetic female infertility · score 0.09
- Female infertility due to fertilization defect · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 55 · score 0.08
- spermatogenic failure 3 · score 0.08
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 61 · score 0.07
- spermatogenic failure 59 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-C9JXX5-F1 | alphafold | PREDICTED | 70.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for C9JXX5.
Amino-acid sequence (98 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FREY1?
The strongest Open Targets associations for FREY1 are azoospermia, Male infertility with spermatogenesis disorder due to single gene mutation, Rare genetic female infertility, Female infertility due to fertilization defect and male infertility with teratozoospermia due to single gene mutation.
How long is the FREY1 protein?
The Homo sapiens FREY1 protein (UniProt C9JXX5) is 98 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB C9JXX5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB C9JXX5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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