RING finger protein 223 (RNF223)
Homo sapiens — UniProt E7ERA6
Data last refreshed: (UniProt release unknown)
Key facts
RING finger protein 223 (RNF223) is a protein from Homo sapiens identified by UniProt accession E7ERA6, 249 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: E7ERA6; gene symbol RNF223.
- Organism: Homo sapiens.
- Length: 249 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, blood protein measurement and serum gamma-glutamyl transferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RING finger protein 223 |
|---|---|
| UniProt accession | E7ERA6 |
| Gene | RNF223 |
| Organism | Homo sapiens |
| Length | 249 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- blood protein measurement · score 0.18
- serum gamma-glutamyl transferase measurement · score 0.13
- pachyonychia congenita · score 0.04
- Hepatic veno-occlusive disease - immunodeficiency · score 0.04
- hepatorenocardiac degenerative fibrosis · score 0.04
- Senior-Boichis syndrome · score 0.04
- kidney disease · score 0.04
- hip bone size · score 0.03
- immunodeficiency 75 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-E7ERA6-F1 | alphafold | PREDICTED | 72.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for E7ERA6.
Amino-acid sequence (249 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF223?
The strongest Open Targets associations for RNF223 are neurodegenerative disease, blood protein measurement, serum gamma-glutamyl transferase measurement, pachyonychia congenita and Hepatic veno-occlusive disease - immunodeficiency.
How long is the RNF223 protein?
The Homo sapiens RNF223 protein (UniProt E7ERA6) is 249 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB E7ERA6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB E7ERA6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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