Small leucine-rich protein 1 (SMLR1)
Homo sapiens — UniProt H3BR10
Data last refreshed: (UniProt release unknown)
Key facts
Small leucine-rich protein 1 (SMLR1) is a protein from Homo sapiens identified by UniProt accession H3BR10, 107 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: H3BR10; gene symbol SMLR1.
- Organism: Homo sapiens.
- Length: 107 amino acids.
- Top disease associations (Open Targets): body height, monocyte count and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small leucine-rich protein 1 |
|---|---|
| UniProt accession | H3BR10 |
| Gene | SMLR1 |
| Organism | Homo sapiens |
| Length | 107 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- body height · score 0.41
- monocyte count · score 0.36
- neuroticism measurement · score 0.35
- monocyte percentage of leukocytes · score 0.33
- creatinine measurement · score 0.33
- platelet count · score 0.32
- urate measurement · score 0.28
- loneliness measurement · score 0.25
- vital capacity · score 0.21
- BMI-adjusted hip circumference · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-H3BR10-F1 | alphafold | PREDICTED | 65.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for H3BR10.
Amino-acid sequence (107 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMLR1?
The strongest Open Targets associations for SMLR1 are body height, monocyte count, neuroticism measurement, monocyte percentage of leukocytes and creatinine measurement.
How long is the SMLR1 protein?
The Homo sapiens SMLR1 protein (UniProt H3BR10) is 107 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB H3BR10 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB H3BR10 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.