Ciliary rootlet coiled-coil protein 2 (CROCC2)

Homo sapiens — UniProt H7BZ55

Gene: CROCC2Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Ciliary rootlet coiled-coil protein 2 (CROCC2) is a protein from Homo sapiens identified by UniProt accession H7BZ55, 1653 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

UniProt accession: H7BZ55; gene symbol CROCC2.
Organism: Homo sapiens.
Length: 1653 amino acids.
Top disease associations (Open Targets): FEV/FVC ratio, refractive error measurement and sex hormone-binding globulin measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	Ciliary rootlet coiled-coil protein 2
UniProt accession	H7BZ55
Gene	CROCC2
Organism	Homo sapiens
Length	1653 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.27
refractive error measurement · score 0.27
sex hormone-binding globulin measurement · score 0.25
body height · score 0.24
vital capacity · score 0.23
forced expiratory volume · score 0.19
BMI-adjusted hip circumference · score 0.19
joint hypermobility measurement · score 0.19
idiopathic hypereosinophilic syndrome · score 0.03
Trimethylaminuria · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-H7BZ55-F1	alphafold	PREDICTED	72.42	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for H7BZ55.

Amino-acid sequence (1653 residues)

MSSASSEPGN GDASQQPLLG LDTVIQRLED TILSPTASRE DRALTVRGEG RQASPTPVPT RIREIVAGSL SEEPPQAGVQ EPTATVARVQ EENELLQEEL TRLGDLLAQA SAERDELASR CRVVSEQLQA RLETTEAQLR RSELEHSVDL EEALGRLEAA EERSTGLCQV NALLREQLEH MKKANDALGR ELAGMTGSVQ RLQGELELRR WAQRQTRSGG LGQPRDLLLL WRQAVVLGTD LAELRVATER GLADLQADTA RTARRLHTAC LNLDSNLRLS ASSTASTLGQ QLRDKAGEML QLQGRWDAEK VALQARLSEQ TLLVEKLTEQ NEQKAKTIAA LRTDLQNLVA QEDARCLELA GSSITELGEP RRPLRSPQRA TSPHQGASPP HICSPATLDP ALQAMRAAIE RRWRREQELC LQLKSSQALV ASLQEQLSES RRELWAAQKL QQERAREQAR EREALRGQLE AQRLEVQQCR ASCKLLGREK AALEMVVEEL KGKADAADAE KQGLEAEAAE LQRSLLLQAE RREELALRRE RSCRALETSQ GRLQQLEEKV SGLREELASV REALSTAQLQ RDVVESEREG LRSALARAEC SNADLELLVR RLKSEGVEQR DSLAAMAALM EGLAQDKSAL NHLALQLEQE RDQLREQRKT LEQERARAGE QLAQAEQQLA LERAERRGLQ QACGRLEQRQ EQLEGQAALL GREKAQLQEQ VGQVTCQKQA LEEQLAQSLQ DQEAQMGTLQ QALQGKDALS EERAQLLAKQ EALERQGRLA AEEAADLRVE RDSLESSLLE AQQLATKLQE QLEEEARSAG LARQALQVEM EQLQSDWEVQ EMKLRQDTVR LQRQVAQQER EAQRALESQA LAHREALAQL QREKETLSLT LAEEKEVARC QLEQEKELVT KSAAEREALK GEIQSLKQER DESLLQLEHK MQQALSLKET ERSLLSEELS RARRTLERVQ QEAQSQQEQA QATISATTEE LKALQAQFED AITAHQRETT ALRESLQDLA AERGDVEREA ERLRAQLTVA QEGLAALRQE LQGVEESREG LHREAQEARR ALSDEAREKD VLLLFNSELR ATICRAEQEK ASFKRSKEEK EQKLLILEEA QAALQQEASA LRAHLWELEQ AGGDARQELR ELHRQVRTLK AENQRRSGEA HELQAQCSQE VLELRRQAAK AEAKHEGARK EVLGLQRKLA EVEAAGEAHG QRLQEHLRES RGAEQTLRAE LHSVTRKLQE ASGVADALQA RLDQACHRIH SLEQELAQAE GARQDAEAQL GRLCSTLRRG LGLQRQSPWA SPEQPGSPTK GSDSSQALPG QQGTSPPARP HSPLRWPSPT PGGRSSELMD VATVQDILRD FVQKLREAQR ERDDSRIQMA TLSSRLSEAE CRCARAQSRV GQLQKALAEA EEGQRRVEGA LSSARAARAL QKEALRRLEL EHLASVRAAG QEKRRLQEQL ETLRQALEES RRHSQGLAKQ GKLLEEQLTN LEHRCQKAEV SLEPLRQMEQ ETLKREEDVA RLGAEKEQLD QSLNSLHQEV DGALRQNQQL QAQMTEMEQA HTQRLQDLTA QHQRDLATEA ERLHGARPQA TQALESQEWT HQQQVKVLEE QVASLKEQLD QEVQWRQQAH LGQAFQTGHA QRD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with CROCC2?

The strongest Open Targets associations for CROCC2 are FEV/FVC ratio, refractive error measurement, sex hormone-binding globulin measurement, body height and vital capacity.

How long is the CROCC2 protein?

The Homo sapiens CROCC2 protein (UniProt H7BZ55) is 1653 amino acids long.

Browse: Targets: C · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB H7BZ55 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB H7BZ55 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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